Morimatsu, Katsumi

Education

B.S., 1990, Biology, Osaka University, Japan

M.S., 1992, Physiology, Osaka University, Japan

Ph.D., 1995, Physiology, Osaka University, Japan

Professional Experience

1994-1997, Research Associate. Research Institute for Microbial Diseases, Osaka University, Japan

1997-1999, Research worker. Institute Curie, France

1999-2000, Research worker. Chalmers University of Technology, Sweden

2000-2003, Postdoctoral fellow. Section of Microbiology, University of California-Davis, USA

2003-2006, Research worker. Chalmers University of Technology, Sweden

2006-Present, Assistant Project Scientist. Microbiology and Molecular Genetics, University of California-Davis, USA

Morimatsu, K. and Horii T. (1995).
Analysis of the DNA binding site of Escherichia coli RecA protein.
Adv Biophys. 31:23-48.

Morimatsu, K. and Horii T. (1995).
The DNA-binding site of the RecA protein. Photochemical cross-linking of Tyr103 to single-stranded DNA.
Eur J Biochem. Mar 15;228:772-8.

Morimatsu, K., Horii, T., and Takahashi, M. (1995).
Interaction of Tyr103 and Tyr264 of the RecA protein with DNA and nucleotide cofactors. Fluorescence study of engineered proteins.
Eur J Biochem. Mar 15;228:779-85.

Morimatsu, K. and Horii, T. (1995).
DNA-binding surface of RecA protein photochemical cross-linking of the first DNA binding site on RecA filament.
Eur J Biochem. Dec 15;234:695-705.

Morimatsu, K., Maraboeuf, F., Hagmar, P., Nordén, B., Horii, T., and Takahashi, M. (1996).
Roles of Tyr103 and Tyr264 in the regulation of RecA-DNA interactions by nucleotide cofactors.
Eur J Biochem. Aug 15;240:91-97.

Morimatsu, K., Morikawa, T., Tanabe, K., Bzik, D.J., and Horii, T. (1997)
Sequence diversity in the amino-terminal 47 kDa fragment of the Plasmodium falciparum serine repeat antigen.
Mol Biochem Parasitol. Jun;86:249-54.

Morimatsu, K., Funakoshi, T., Horii, T., and Takahashi, M. (2001).
Interaction of tyrosine 65 of RecA protein with the first and second DNA strands.
J Mol Biol. Feb 16;306:189-99.

Morimatsu, K., Takahashi, M., and Nordén, B. (2002).
Arrangement of RecA protein in its active filament determined by polarized-light spectroscopy.
Proc Natl Acad Sci U S A. Sep 3;99:11688-93.

Kim, H.K., Morimatsu, K., Nordén, B., Ardhammar, M., and Takahashi, M. (2002).
ADP stabilizes the human Rad51-single stranded DNA complex and promotes its DNA annealing activity.
Genes Cells. Nov;7:1125-34.

Stohl, E.A., Brockman, J., Burkle, K.L., Morimatsu, K, Kowalczykowski, S.C., and Seifert, H.S. (2003).
Escherichia coli RecX inhibits RecA recombinase and coprotease activities in vitro and in vivo.
J. Biol. Chem., 278, 2278-2285 (published November 9, 2002 as 10.1074/jbc.M210496200). PMID: 12427742. [Abstract] [Full Text] [PDF]

Morimatsu, K. and Kowalczykowski, S.C. (2003).
RecFOR proteins load RecA protein onto gapped DNA to accelerate DNA strand exchange: A universal step of recombinational repair.
Mol. Cell, 11, 1337-1347. PMID: 12769856. [Abstract] [Full Text] [PDF]

Frykholm, K., Morimatsu, K., and Nordén, B. (2006).
Conserved conformation of RecA protein after executing the DNA strand-exchange reaction. A site-specific linear dichroism structure study.
Biochemistry. Sep 19;45:11172-8.

Morimatsu, K. and Takahashi, M. (2006).
Structural analysis of RecA protein-DNA complexes by fluorescence-detected linear dichroism: absence of structural change of filament for pairing of complementary DNA strands.
Anal. Biochem. Nov 15;358:192-8.

Takahashi, M., Maraboeuf, F., Morimatsu, K., Selmane, T., Fleury, F., and Nordén, B. (2007).
Calorimetric analysis of binding of two consecutive DNA strands to RecA protein illuminates mechanism for recognition of homology.
J. Mol. Biol. 365, 603-611. PMID: 17097680.

Reymer, A., Frykholm, K., Morimatsu, K., Takahashi, M., and Nordén, B. (2009).
Structure of human Rad51 protein filament from molecular modeling and site-specific linear dichroism spectroscopy.
Proc. Natl. Acad. Sci. (USA) 106, 13248-13253, doi: 10.1073/pnas.0902723106. PMID: 19587234; PMCID: PMC2726390.

Handa, N., Morimatsu, K., Lovett, S.T., and Kowalczykowski, S.C. (2009)
Reconstitution of initial steps of dsDNA break repair by the RecF pathway of E. coli.
Genes & Dev., 23, 1234-1245. PMID: 19451222; PMCID: PMC2685532 [Abstract] [Full Text] [PDF] [Supplemental Material]
(see Current Biology Dispatch: DNA Repair: Common Approaches to Fixing Double-Strand Breaks [PDF])

Morimatsu, K., Wu, Y., and Kowalczykowski, S.C. (2012)
RecFOR proteins target RecA protein to a DNA gap with either DNA or RNA at the 5' terminus: Implication for repair of stalled replication forks.
J. Biol. Chem. 287, 35621-35630 (published online 17 August 2012 as 10.1074/jbc.M112.397034). PMID: 22902627; PMCID: PMC3471720 [Abstract] [Full Text] [PDF] [Supplemental Information]

Morimatsu, K. and Kowalczykowski, S. C. (2014)
RecQ helicase and RecJ nuclease provide complementary functions to resect DNA for homologous recombination.
Proc. Natl. Acad. Sci. U.S.A., (published online November 19, 2014 as doi: 10.1073/pnas.1420009111). PMID: 25411316; PMCID: PMC4260596. [Abstract] [Full Text] [PDF] [Supporting Information]