Pavankumar, Theetha

 

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Theetha Pavankumar

B. Pharma, 1998, Pharmacy, Government College of Pharmacy, Bangalore, India

M. Pharma, 2002, Pharmacology, Government College of Pharmacy, Bangalore, India

Ph.D., 2009, Life Sciences (Bacterial Genetics, Molecular Biology and Biochemistry, Jawaharlal Nehru University, New Delhi

Postdoctoral Scholar, 2009-2015, Biochemistry, University of California, Davis, CA

Assistant Project Scientist, 2015-present, University of California, Davis, CA
   

A complete academic profile can be found at orcid.org/0000-0003-1845-9592 and www.webofscience.com/wos/author/record/R-6118-2017.

Publications:

Pavankumar TL*, Rai N, Pandey PK, Vincent N. Helicases at Work: The Importance of Nucleic Acids Unwinding Under Cold Stress. DNA. 2024; 4(4):455-472. doi.org/10.3390/dna4040031 *Corresponding author.

Pavankumar TL, Liu B, Amitani I, Kowalczykowski SC (2024). Lead DNA motor usage by RecBCD enzyme is controlled by RecB nuclease and χ-recognition. Proc. Natl. Acad. Sci. U.S.A (under revision).

Pavankumar TL, Wong CJ, Wong YK, Spies M, Kowalczykowski SC. Trans-complementation by the RecB nuclease domain of RecBCD enzyme reveals new insight into RecA loading upon χ recognition. Nucleic Acids Res. 2024 Mar 21;52(5):2578-2589. doi.org/10.1093/nar/gkae007.

Pavankumar, TL. RNase R vs. PNPase: selecting the best-suited exoribonuclease for environmental adaptation. Extremophiles 28, 35 (2024). doi.org/10.1007/s00792-024-01350-6.

Mittal P, Sinha AK, Pandiyan A, Kumari L, Ray MK, Pavankumar TL*. A type II toxin-antitoxin system is responsible for the cell death at low temperature in Pseudomonas syringae Lz4W lacking RNase R. J Biol Chem. 2024 Aug;300(8):107600. doi.org/10.1016/j.jbc.2024.107600. *Lead corresponding author.

Mittal P, Sipani R, Pandiyan A, Sulthana S, Sinha AK, Hussain A, Ray MK, Pavankumar TL*. 2023. Exoribonuclease RNase R protects Antarctic Pseudomonas syringae Lz4W from DNA damage and oxidative stress. Appl Environ Microbiol 89:e01168-23. doi.org/10.1128/aem.01168-23. *Lead corresponding author.

Pavankumar TL*, Mittal, P. and Hallsworth, J.E. (2021), Molecular insights into the ecology of a psychrotolerant Pseudomonas syringae. Environ Microbiol. doi.org/10.1111/1462-2920.15304. *Corresponding author.

Pavankumar, T.L., Sinha, A.K., and Ray, M.K. (2018).
Biochemical characterization of RecBCD enzyme from an Antarctic Pseudomonas species and identification of its cognate Chi (x) sequence.
PLoS One May 18;13(5):E0197476. doi: 10.1371/journal.pone.0197476. PMID: 29775464; PMCID: PMC5959072.

Pavankumar, T.L. (2018).
Inteins: Localized distribution, gene regulation, and protein engineering for biological applications.
Microorganisms Feb 28;6(1): pii: E19, doi: 10.3390/microorganisms6010019. PMID: 29495613; PMCID: PMC5874633.

Pavankumar, T.L., Exell, J.C., and Kowalczykowski, S.C. (2016).
Direct fluorescent imaging of translocation and unwinding by individual DNA helicases.
Methods Enzymol. 581, 1-32. doi: 10.1016/bs.mie.2016.09.010. Epub 2016 Oct 18. PMID: 27793277; PMCID: PMC5854184.

Pindi, P.K., R, R.S., and Pavankumar, T.L. (2014).
Isolation and characterization of novel lipase gene LipHim1 from the DNA isolated from soil samples.
J. Microbiol. 52:384-388. doi: 10.1007/s12275-014-3302-2. Epub 2014 Apr 11. PMID: 24723100.

Sinha, A.K., Pavankumar, T.L., Kamisetty, S., Mittal, P., and Ray, M.K. (2013).
Replication arrest is a major threat to growth at low temperature in Antarctic Pseudomonas syringae Lz4W.
Mol. Microbiol. 89: 792-810. doi: 10.1111/mmi/12315. Epub 2013 July 19. PMID: 23815755.

Pavankumar, T.L., Sinha, A.K., and Ray, M.K. (2010).
All three subunits of RecBCD enzyme are essential for DNA repair and low-temperature growth in the Antarctic Pseudomonas syringae Lz4W.
PLoS One Feb 25;5:e9412. doi: 10.1371/journal.pone.0009412. PMID: 20195537, PMCID: PMC2828478.

Satapathy, A.K., Pavankumar, T.L., Bhattacharjya, S., Sankaranarayanan, R., and Ray, M.K. (2008).
ATPase activity of RecD is essential for growth of the Antarctic Pseudomonas syringae Lz4W at low temperature.
FEBS J. 2008 Apr;275,1835-1851. doi: 10.1111/j.1742-4658.2008.06342.x. Epub 2008 Mar 9. PMID: 18336576.