Hilario, Jovencio

 

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Jovencio Hilario

B.S., 1994, Biochemistry - University of Illinois at Chicago; Chicago, IL

M.S., 1995, Chemistry - University of Illinois at Chicago; Chicago, IL

Ph.D., 2004, Chemistry -University of Illinois at Chicago; Chicago, IL

Postdoctoral Fellow, 2004-2009 - University of California, Davis, CA

  Current address:

Senior Scientist
Bio-Rad Laboratories
4000 Alfred Nobel Drive
Hercules, CA 94547
(510) 724-7000

Riccelli, P.V., Hilario, J., Gallo, F.J., Young, A.P., and Benight, A.S.  (1998).
DNA and RNA oligomer sequences from the 3’ noncoding region of the chicken glutamine synthetase gene form intramolecular hairpins.
Biochemistry, 35, 15364-15372.

Vallone, P. M., Paner, T. M., Hilario, J., Lane, M. J., Faldasz, B. D., and Benight, A. S. (1999).
Melting studies of short DNA hairpins: Influence of loop sequence and adjoining base pair identity on hairpin thermodynamic stability.
Biopolymers, 50, 425-442.

Hilario, J., Drapcho, D., Curbelo, R., and Keiderling, T. A. (2001).
Polarization modulation Fourier transform infrared spectroscopy with digital signal processing. Comparison of vibrational circular dichroism methods.
Applied Spectroscopy, 55, 1435-1447.

Hilario, J., Kubelka, J., Syud, F. A., Gellman, S. H., and Keiderling, T. A. (2002). 
Spectroscopic characterization of selected β-sheet hairpin models.
Biopolymers (Biospectroscopy), 67, 233-236.

Kuznetsov, S.V., Hilario, J., Keiderling, T.A., and Ansari, A. (2003).
Spectroscopic studies of structural changes in two β-sheet forming peptides show an ensemble of structures that unfold non-cooperatively.
Biochemistry, 42, 4321-4332.

Hilario, J., Kubelka, J., and Keiderling, T.A. (2003).
Optical spectroscopic investigations of model β-sheet hairpins in aqueous solution.
J. Am. Chem. Soc., 125, 7562-7574,

Keiderling, T.A., Kubelka, J., Hilario, J. (2006).
Vibrational circular dichroism of biopolymers: Summary of methods and applications.
In Vibrational spectroscopy of biologic and polymeric materials; Gregoriou, V. and Braiman, M., Ed.; CRC Taylor & Francis, Boca Raton, FL
.

Hilario, J., Amitani, I., Baskin, R.J., and Kowalczykowski, S.C. (2009)
Direct imaging of human Rad51 nucleoprotein dynamics on individual DNA molecules.

Proc. Natl. Acad. Sci. U.S.A., 106
, 361-368 (published online January 2, 2009, doi: 10.1073/pnas.0811965106.) PMID: 19122145; PMCID: PMC2613362
[Abstract] [Full Text] [PDF] [Supporting Information] [Movie 1] [Movie 2] [Movie 3]
(see About Medicine: Fluorescent microscopy captures the repair protein Rad51 as it assembles into a filament on DNA [PDF])
(see Biocompare News: Human DNA repair process recorded in action [PDF])
(see Biology News Net: Human DNA repair process recorded in action [PDF])
(see Biophotonics: Mending broken DNA [PDF])

(see e! Science News: Human DNA repair process recorded in action [PDF])
(see EurekAlert: Human DNA repair process recorded in action [PDF])
(see Insciences Organisation: Human DNA repair process recorded in action [PDF])

(see Machines Like Us, News: Human DNA repair process recorded in action [PDF])
(see MacNewsWorld: EurekAlert: Human DNA repair process recorded in action [PDF])
(see Medical News Today: Fluorescent microscopy captures the repair protein Rad51 as it assembles into a filament on DNA [PDF])
(see Newsguide.us: Human DNA repair process recorded in action [PDF])
(see Newsweek, National News: Human DNA repair process recorded in action (Video) [PDF])
(see Overwhelming Evidence: Human DNA repair process video - by chance? [PDF])
(see Phys.org/News: Human DNA repair process recorded in action (Video) [PDF])
(see ScienceBlog: Human DNA repair process recorded in action [PDF])
(see Science Codex: Human DNA repair process recorded in action [PDF])
(see Science Daily: Human DNA repair process recorded in action [PDF])
(see ScienceMode.com: Human DNA repair process recorded in action [PDF])
(see The Sensuous Curmudgeon: Human DNA repair process recorded [PDF])
(see UCDavis News and Information: Human DNA repair process recorded in action Caught in the act: Our DNA under repair  [Video] [Printable])
(see Uncommon Descent: Human DNA repair process video - by chance? [PDF])

Carreira, A., Hilario, J., Amitani, I., Baskin, R.J., Shivji, M.K.K., Venkitaraman, A.R., and Kowalczykowski, S.C. (2009)
The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51.

Cell, 136,
1032-1043, (doi:10.1016/j.cell.2009.02.019). PMID: 19303847; PMCID: PMC2669112  [Abstract] [Full Text] [PDF] [Supplemental Data]
(see Cell, In this Issue: BRCA2 Focuses RAD51 for Repair  [PDF])
Access the recommendation on F1000Prime

Hilario, J. and Kowalczykowski, S.C. (2010).
Visualizing protein-DNA interactions at the single-molecule level.

Curr. Opin. Chem. Biol.,
14, 15-22. PMID: 19945909; PMCID: PMC2819561 [Abstract] [Full Text] [PDF]