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Jack Exell
M.S., 2008,
Biological Chemistry - University of Sheffield, UK
Ph.D., 2015,
Mechanism of hFEN1 inhibition - University of Sheffield, UK
Postdoctoral
Scholar, 2015-present, University of California, Davis, CA
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Patel, N., Atack J.M., Finger, L.D.,
Exell, J.C., Thompson, P., Tsutakawa, S.E., Tainer, J.A., Williams, D.M., and
Grasby J.A. (2012).
Flap endonucleases pass 5' flaps through a flexible arch using a
disorder-thread-order mechanism to confer specificity for free 5' ends.
Nucleic Acids Res. 40, 4507-4519. PMID: 22319208; PMCID: PMC3378889.
Finger, L.D., Patel, N., Beddows, A., Ma, L., Exell, J.C., Jardine, E.,
Jones, A,C., and Grasby J.A. (2013). Observation of
unpaired substrate DNA in
the flap endonuclease-1
active site.
Nucleic Acids Res.
41, 9839-9847.
PMID: 23975198; PMCID: PMC3834815.
Patel, N., Exell, J.C., Jardine, E., Ombler, B., Finger, L.D., Ciani, B.,
and Grasby J.A. (2013).
Proline scanning mutagenesis
reveals a role for the
flap endonuclease-1
helical cap in
substrate unpairing.
J. of
Biol. Chem.
288, 34239-34248. PMID:
24126913; PMCID: PMC3837164.
Pavankumar, T.L., Exell,
J.C., and Kowalczykowski, S.C. (2016).
Direct fluorescent imaging of translocation and unwinding by individual DNA
helicases.
Methods Enzymol. 581, 1-32. doi: 10.1016/bs.mie.2016.09.010. Epub
2016 Oct 18. PMID: 27793277; PMCID: PMC5854184.
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