Faculty of 1000 | RecBCD enzyme is a bipolar DNA helicase.

Welcome Stephen Kowalczykowski

Last visit : 3-Nov-2004

Must Read

F1000 Factor 6.0

RecBCD enzyme is a bipolar DNA helicase.
Dillingham MS, Spies M, Kowalczykowski SC
Nature 2003 Jun 19 423(6942):893-7 [abstract on PubMed] [related articles] [order article]

Selected by | Phoebe Rice
Evaluated 11 Aug 2003

Relevant Sections

Faculty Comments

Faculty Member

Comments

Phoebe Rice
University of Chicago, United States
STRUCTURAL BIOLOGY

New Finding

Two different groups [1] have now conclusively shown that the RecBCD complex, which is important in the intial steps of DNA double-strand break repair in E. coli, contains two simultaneously active helicases. The two helicases load at a broken end, then proceed with opposite polarities, presumably one down each strand. This has interesting implications for how RecBCD produces the recombinogenic ssDNA tails that it then passes off to RecA, and for the mechanisms of certain other protein complexes involved in DNA repair. [1] See also Taylor & Smith, Nature 2003, 423:889 [PMID:12815437].

Evaluated 11 Aug 2003

cite this evaluation

Faculty Comments

How to cite the Faculty of 1000 evaluation(s) for this paper

1) To cite all the evaluations for this article:

Faculty of 1000: evaluations for Dillingham MS et al Nature 2003 Jun 19 423 (6942) :893-7 http://www.f1000biology.com/article/12815438/evaluation

2) To cite an evaluation by a specific Faculty member:

Phoebe Rice: Faculty of 1000, 11 Aug 2003 http://www.f1000biology.com/article/12815438/evaluation

Published by